GC Image LCxLC Edition Users' Guide

New Features and Improvements in Version 2020

GC Image LCxLC Edition 2020 has many new features and improvements. See the GC Image LCxLC Edition Users' Guide for full documentation.

What's New in Version 2020 Release 1.1 (September 2020)

Support for NIST 2020 MS and MS/MS Libraries

Version 2020R1.1 has an updated batch search interface that is fully compatible with the latest NIST 2020 libraries including the updated RI library, and the new MS/MS libraries that double in coverage.

What's New in Version 2020 Release 1 (July 2020)

Improved 64-bit Performance

Version 2020R1 includes a new 64-bit framework that provides improved performance and system stability for all operations when processing data larger than 2GB. Due to the new framework, the software no longer supports the Microsoft Windows Vista or older operating systems.

Command Line Interface for Batch Processing and Advanced Workflows

Version 2020R1 introduces the Command Line interface that allows processing a single raw data file or re-processing a chromatographic image with a Method or scripting. The interface can be used to create workflows that integrate multiple tools or software for automating routine analysis or complicated processing with a large number of data files.

New Improvements for Retention Index Calibration

Version 2020R1 has new improvements on generic retention index calibration especially for batch processing, including:

A new Retention Index Method (.gcrm) file that allows the user to export and import the RI table and settings together either manually or through a Method;
Default retention index calibration settings now can be configured and exported through Configure > Settings along with other settings;
Import and Refresh an RI table now keeps current settings;
A clear error message, instead of an empty table, is displayed if a linked RI table file is empty or invalid.

In addition, the software now supports

Base 10, in addition to natural log, for the log-linear regression;
Converting other retention properties of a blob to retention indices with two new CLIC functions, LRI1() and LRI2().

Version 2020R1 has new options for molecular weight calibration with GPC, including:

Mz+1 molecular weight average property that can be added to Blob Table;
Calibration Type - GPC option that computes molecular weight averages from responses acquired by a concentration detector such as refractive index detector;
Mark-Houwink constants that can be specified for standard and sample polymers to perform universal calibration.

New and Improved Support for Extracting Ion Peaks

Version 2020R1 has two new filters for Processing > Extract Ion Peaks as Areas:

New Min Qualifier Ion Count filter that allows the user to specify the minimum number of apexing ions required;
New CLIC Filter that allows the user to specify a customized constraint using all properties computed for a targeted ion apex peak, for example, retention times or a combination of peak width and qualifier ions.

The operation now can be added to a Method, and supported by batch processing with Project or the Command Line interface.

In addition, the Context MS mode has the following improvements to make it easier to examine spectra deconvolved by the operation, including:

Reference MS, where the deconvolved spectrum are stored, is loaded to the MS View automatically;
Only the primary spectra are set to be visible by default for a less cluttered display;
A spectrum can be set to Active and Visible separately to allow fast toggling of the displayed spectra in MS Viewer.

New Improvements for Investigator

Version 2020R1 has new improvements for Investigator, including:

Spectra view in the Compounds Perspective now supports sending a selected spectrum to the NIST Library for identification search.
Compound Finder now displays the results next to the main perspectives, which allows cross examining the information of resulting compounds from the main perspectives.

Other New Improvements

Version 2020R1 has other improved operations, including:

Interactive Blob Detection now has a new Apply and Save as Defaults button that allows the user to save detection settings as the default configuration. The button replaces the old Set-to-Configuration option and question.
Interactive Blob Detection now sets only the Min threshold, instead of both Min and Max thresholds, by default when SNR or other threshold-based suggested properties are added.
The software now supports smaller font sizes (i.e. 4 - 7) than 8 for Text annotation on small chromatogram images.

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